Stressrelaterad ohälsa

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BMC Complementary and Alternative Medicine 2013, 13:308

Effects of an integrative treatment, therapeutic

acupuncture and conventional treatment in alleviating psychological distress in primary care patients - a pragmatic randomized controlled trial

Background: To evaluate and compare effects of an integrative treatment (IT), therapeutic acupuncture (TA), and

conventional treatment (CT) in alleviating symptoms of anxiety and depression in psychologically distressed primary

care patients.

Methods: An open, pragmatic randomized controlled trial comparing the three treatment regimens at four and

eight weeks after treatment. The study sample consisted of 120 adults (40 per treatment arm) aged 20 to 55 years

referred from four different primary health care centres in western Sweden for psychological distress. Psychological

distress was evaluated at baseline, and after 4 and 8 weeks of treatment using the Hospital Anxiety and Depression

scale (HAD). Treatment sessions lasted about 60 minutes in IT and 45 minutes in TA.

Results: No baseline differences were found between groups on HAD depression or anxiety. HAD anxiety and

depression decreased significantly more in the IT and TA groups than in the CT group both after 4 and 8 weeks of

treatment, but not between IT and TA. Improvements in the TA and IT groups were large and clinically significant,

whereas CT effects were small and clinically non-significant.

Conclusions: Both IT and TA appear to be beneficial in reducing anxiety and depression in primary care patients

referred for psychological distress, whereas CT does not. These results need to be confirmed in larger, longer-term studies addressing potentially confounding design issues in the present study.

Tina Arvidsdotter et al.

 Ung kvinna Överväger

 Journal of Clinical Sleep Medicine

2011;7(1):95-102. 

Autonomic Activation in Insomnia: The Case for Acupuncture 

Current conceptualizations of the biological basis for insomnia typically invoke central nervous system and/or autonomic nervous system arousal. Acupuncture may represent a unique avenue of treatment for poor sleep by virtue of its direct effects on peripheral nerves and muscles, which, in turn, modulate autonomic tone and central activation. In this review, we summarize both basic and clinical research indicating that acupuncture exerts profound influences via a wide variety of potential neural and/or hormonal mechanisms that have great relevance for the modulation of sleep and wakefulness. We illustrate principles of acupuncture intervention applied to cases of otherwise intractable insomnia that document successful application of this component of Traditional Chinese Medicine to the treatment of poor sleep. Our review indicates the necessity for further research in the relationship between the effects of acupuncture on insomnia and autonomic regulation, which might guide better selective use of this treatment modality for insomnia. 

 Wei Huang et al.

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Complementary Therapies in Clinical Practice 21 (2015) 

Acupuncture-induced changes of vagal function in patients with

depression: A preliminary sham-controlled study with press needles

To study the biological effects of acupuncture on depression, we hypothesized that acupuncture will

exert its antidepressant effect through a bottom-up neuromodulation of the autonomic dysfunction in

depression. The participants received press needle (PN) acupuncture for 72 h continuously in a shamcontrolled

design. Psychological assessments and Holter electrocardiography were performed before

and after PN acupuncture. We evaluated their autonomic functions through the heart rate variability

(HRV). As a result, following PN acupuncture participants showed significant improvement in the Beck's

Depression Inventory scores (P . 0.031), systolic/diastolic blood pressures (P . 0.002/P . 0.011), and

coefficient of variation of the ReR interval (P < 0.0001), compared to sham PN. The present findings

showed PN acupuncture induced alterations in vagal function, blood pressure, and Beck's Depression

Inventory scores. It was suggested that vagal stabilization effect by acupuncture may be associated with

the therapeutic mechanism in depression.

Yoshihiro Noda et al.

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September 2017

Acupuncture and Connective Tissue - Learn more about connective tissue.

Gå in och lyssna på Youtube till       Dr Helena Langevin MD             Director for Osher Centre for Integrative Medicine. 

Lyssna till hennes och kollegors forskning om Akupunktur.

February  2019

Default Mode Network as a Neural Substrate of Acupuncture: Evidence, Challenges and Strategy.

Acupuncture is widely applied all over the world. Although the neurobiological underpinnings of acupuncture still remain unclear, accumulating evidence indicates significant alteration of brain activities in response to acupuncture. In particular, activities of brain regions in the default mode network (DMN) are modulated by acupuncture. DMN is crucial for maintaining physiological homeostasis and its functional architecture becomes disrupted in various disorders. But how acupuncture modulates brain functions and whether such modulation constitutes core mechanisms of acupuncture treatment are far from clear. This Perspective integrates recent literature on interactions between acupuncture and functional networks including the DMN, and proposes a back-translational research strategy to elucidate brain mechanisms of acupuncture treatment.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378290/pdf/fnins-13-00100.pdf

Yuqi Zhang et al. 2019

Frontiers in Neuroscience 

April 2020

Activation of LXRβ Signaling in the Amygdala Confers Anxiolytic Effects Through Rebalancing Excitatory and Inhibitory Neurotransmission upon Acute Stress.

The balance of major excitatory (glutamate, Glu) and inhibitory (γ-aminobutyric acid, GABA), named as E/I neurotransmission, is critical for proper information processing. Anxiety-like responses upon stress are accompanied by abnormal alterations in the formation and function of synapses, resulting in the imbalance of E/I neurotransmission in the amygdala. Liver X receptors (LXRs), including LXRα and LXRβ isoforms, are nuclear receptors responsible for regulating central nervous system (CNS) functions besides maintaining metabolic homeostasis. However, little is known about the contribution of LXRs in E/I balance in regulating anxiety-related behaviors induced by stress. In this study, we found stress-induced anxiety led to the expression reduction of LXRβ not LXRα in mice amygdala. GW3965, a dual agonist for both LXRα and LXRβ, alleviated anxiety-like behaviors of stressed mice through activation of LXRβ, confirmed by the knockdown of LXRβ mediated by lentiviral shRNAs in the basolateral amygdala (BLA). This was paralleled by correcting the disequilibrium of E/I neurotransmission in the stressed BLA. Importantly, GW3965 exerted anxiolytic effects by correcting the promoted amplitude and frequency of miniature excitatory postsynaptic current (mEPSC), and augmenting the decreased that of miniature inhibitory postsynaptic current (mIPSC) in the stressed BLA. This suggests that stress-induced anxiety-like behaviors can largely be ascribed to the deficit of LXRβ signaling in E/I neurotransmission in BLA. These findings highlight the deficiency of LXRβ signaling in the amygdala linked to anxiety disorder, and LXRβ activation may represent a potential novel target for anxiety treatment with an alteration in synaptic transmission in the amygdala.

Yu W et al. 

Neurotherapeutics (2020)